Combining Alprazolam XR With Other Medicines

Cimetidine
Combining alprazolam XR with cimetidine can increase the amount of alprazolam XR in your blood, potentially increasing your risk of side effects. Do not take these medications together without your healthcare provider's approval. Most likely, your healthcare provider will recommend taking one of the many cimetidine alternatives that do not interact with alprazolam XR.
 
Delavirdine
Taking alprazolam XR with delavirdine can increase the amount of alprazolam XR in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your alprazolam XR dosage to prevent this interaction from occurring.
 
Grapefruit Juice
Grapefruit juice can increase the level of alprazolam XR in your blood, potentially increasing your risk of side effects of alprazolam XR. It is best to avoid grapefruit juice while taking the drug. However, if your healthcare provider decides that it is okay for you to drink grapefruit juice, you should do so consistently and in moderation.
 
Narcotics or Opiates
Combining an opiate or narcotic with alprazolam XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking these medications together.
 
Nefazodone
Nefazodone can double the amount of alprazolam XR in your blood, greatly increasing your risk of side effects. Do not take these medications together without your healthcare provider's approval.
 
Oral Contraceptives
Taking alprazolam XR with oral contraceptives (also known as birth control pills) can increase the amount of alprazolam XR in your blood, possibly increasing your risk of side effects. Depending on your particular situation, your healthcare provider may need to lower your alprazolam XR dosage or may recommend another form of birth control.
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