Drug Interactions With Alprazolam XR

Drug interactions with Alprazolam XR can occur when it is combined with antipsychotic medicines, antidepressants, or sleep medications. These interactions can lead to an increased risk of side effects (including difficulty breathing, confusion, drowsiness, and memory loss). Therefore, in order to ensure a safe treatment process, talk with your healthcare provider about the specific drug interactions with alprazolam XR that may apply to you.

An Overview of Drug Interactions With Alprazolam XR

 Alprazolam XR (Xanax XR®) can potentially interact with many other medications. Some of the medicines that may lead to alprazolam XR interactions include:
 
  • Alcohol
 
 
 
 
  • Barbiturates, including:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Certain antibiotics or antifungals, including:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
 
 
  • Grapefruit juice
 
  • Narcotics or opiates, such as:
 
 
 
 
  • Other benzodiazepines, including:
 
 
  • Protease inhibitors, such as:
 
 
 
  • Sleep medications.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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