Taking Other Medicines With Anafranil

Barbiturates
Taking Anafranil with barbiturates can increase the risk of side effects of both Anafranil and barbiturates, such as drowsiness or dizziness. It is also possible that taking these medications together could decrease the level of Anafranil in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Buspirone (BuSpar)
Because combining Anafranil with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking Anafranil with cimetidine can increase the level of Anafranil in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your Anafranil dosage or suggest an alternative to cimetidine.
 
Clonidine (Catapres)
Anafranil may make clonidine less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Digoxin (Digitek, Lanoxin)
Taking Anafranil with digoxin can increase the effects of digoxin, which can lead to dangerous side effects. Your healthcare provider may need to monitor you more closely or adjust your digoxin dosage.
  
Fentanyl
Combining Anafranil with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Anafranil with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining Anafranil with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Linezolid (Zyvox)
Taking Anafranil with linezolid can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
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Anafranil Drug Information

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