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from eMedTV.comMethylphenidate
Methylphenidate can increase the level of Anafranil in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Anafranil dose.
Monoamine Oxidase Inhibitors (MAOIs)
Taking Anafranil with MAOIs can increase your chance of developing dangerous side effects. Do not take Anafranil if you have taken an MAOI within the past two weeks.
Phenothiazines
Taking Anafranil with phenothiazine medications can increase the level of Anafranil in your blood, increasing your risk of side effects. Also, combining Anafranil with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.
Phenytoin (Dilantin)
Phenytoin can decrease the level of Anafranil in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Anafranil dose.
Pressors
Taking Anafranil with pressor medications can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
SSRIs or SNRIs
Taking Anafranil with SSRIs or SNRIs can increase the level of Anafranil in your blood, increasing your chance of side effects and increasing the risk for serotonin syndrome. Your healthcare provider may need to adjust your dose of these medications or use caution when switching from one medicine to another.
St. John's Wort
Combining Anafranil with St. John's wort may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD