Anafranil Drug Interactions

Anafranil drug interactions with other medications, such as anticholinergic medications, arrhythmia medications, or thyroid medications, can cause the body to metabolize the medications differently than intended. Some of these drug interactions with Anafranil can increase the amounts of certain medications in the blood, increasing your risk of side effects or increasing your risk of a dangerous arrhythmia called QT prolongation. Your healthcare provider may need to adjust your dosage of these medications.

 

Anafranil Drug Interactions: An Introduction

Anafranil® (clomipramine hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Anafranil interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide(Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®) 
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®) 
  • Thyroid medications, including:
o Liothyronine (Cytomel®)
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®) 
  • Warfarin (Coumadin®, Jantoven®).
     
(Anafranil Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;