Important Safety Info on Anafranil

Some Anafranil Warnings and Precautions

Some Anafranil warnings and precautions to be aware of include:
  • Even though Anafranil is not licensed to treat depression, it is classified as an antidepressant based on how it works in the brain. Antidepressants (including Anafranil) may increase the risk of suicidal thinking or behavior in children, teenagers, and adults (see Clomipramine and Suicide for more information). Therefore, if you notice any changes in symptoms or develop new symptoms, talk to your healthcare provider immediately. Some of these symptoms may include: anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thinking or behavior.
  • Before prescribing Anafranil, your healthcare provider should make sure that you do not have bipolar disorder, as Anafranil can cause problems in people with bipolar disorder.
  • Anafranil can cause low white blood cell counts, which can increase your risk of infection. Tell your healthcare provider if you have symptoms of an infection, such as a fever or sore throat. Seek medical attention immediately if you have a very high fever, as this may be a sign of a dangerous side effect (hyperthermia).
  • Anafranil can cause sexual problems, especially in men (see Clomipramine Sexual Side Effects). It can also cause weight gain (see Clomipramine and Weight Gain).
  • For people taking Anafranil, caution should be used when driving, operating heavy machinery, or performing other tasks that require concentration, especially when first starting Anafranil or when switching dosages. This is because Anafranil may affect a person's mental or physical ability to perform these tasks. Make sure you understand how Anafranil affects you before performing any task that requires mental or physical concentration.
  • Anafranil can interact with certain medications (see Anafranil Drug Interactions).
  • Anafranil may enhance the effects of alcohol, barbiturates, and other medicines that affect the brain. This can lead to an increased risk for drowsiness, dizziness, suicidal thoughts, and other Anafranil overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking Anafranil.
  • The U.S. Food and Drug Administration (FDA) considers Anafranil a pregnancy Category C medicine. This means that Anafranil may not be safe for use in pregnancy. Discuss the benefits and risks of using Anafranil during pregnancy with your healthcare provider (see Clomipramine and Pregnancy for more information).
  • Anafranil passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about what makes the most sense for your particular situation.
  • Special care should be used when taking Anafranil if you have seizures, heart disease, glaucoma, an adrenal tumor, liver problems, or kidney disease.
  • Talk to your healthcare provider before taking Anafranil if you have hyperthyroidism (an overactive thyroid) or take thyroid medication.
  • Do not stop taking Anafranil without first discussing it with your healthcare provider. Stopping the medicine abruptly may increase the risk of withdrawal symptoms (see Clomipramine Withdrawal).
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Anafranil Drug Information

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