Taking SNRIs or Tricyclic Antidepressants for Anxiety

Serotonin-Norepinephrine Reuptake Inhibitors
Serotonin-norepinephrine reuptake inhibitors (SNRIs) are closely related to SSRIs. They have similar actions as SSRIs, although they have a tendency to have more "stimulatory" effects, probably due to the effects on norepinephrine. This can become a problem for some people who may experience insomnia or jitteriness. Others may develop high blood pressure as a result of the norepinephrine effects.
 
SNRI medications include:
 
Not all SNRIs are approved for anxiety treatment.
 
Tricyclic Antidepressants
Tricyclic antidepressants have been around longer than SSRIs and have been more widely studied as a treatment for anxiety. However, they are generally more likely to cause intolerable or even dangerous side effects and (as a result) are not usually good choices for elderly individuals. Some of the potential side effects of tricyclic antidepressants include:
 
If these problems persist or are bothersome, a change in dosage or a switch in medications may be needed. Tricyclics are especially useful when treating anxiety in people with co-occurring anxiety disorders and depression.
 
Examples of tricyclic antidepressants include:
 
Not all tricyclic antidepressants are approved to treat anxiety.
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