Duloxetine hydrochloride (HCl) is sold under the brand name Cymbalta® and is licensed to treat the following conditions:
- Depression (also known as major depression or clinical depression)
- Peripheral diabetic neuropathy pain
- Generalized anxiety disorder (GAD)
- Chronic musculoskeletal pain, such as arthritis pain or back pain.
The medication works by increasing the levels of certain chemicals in the brain (serotonin and norepinephrine) and possibly by blocking the nerve pain signals in the spinal cord or brain. Duloxetine comes in capsule form and is taken once or twice a day.
(Click Duloxetine to learn more about this medication, including information on possible side effects, generic availability, and what to do if you are pregnant or breastfeeding.)