Serotonin-Norepinephrine Reuptake Inhibitors
If you have depression, your healthcare provider may recommend taking a serotonin-norepinephrine reuptake inhibitor (SNRI). Five SNRIs are currently available:
- Duloxetine (Cymbalta®)
- Venlafaxine (Effexor®)
- Venlafaxine XR (Effexor XR®)
- Desvenlafaxine (Pristiq™)
- Milnacipran (Savella™).
SNRIs work by balancing the levels of serotonin and norepinephrine in the brain. Depending on the product being used, they are typically taken one to three times a day.
Although SNRIs were initially used for depression, some of them are now approved for additional uses, such as the treatment of:
- Generalized anxiety disorder (GAD)
- Panic disorder
- Peripheral diabetic neuropathy pain (nerve pain in the hands, feet, arms, or legs due to diabetes).
(Click SNRIs for details on the side effects, safety, and effectiveness of serotonin-norepinephrine reuptake inhibitors.)