Ativan Drug Interactions

Divalproex (Depakote, Depakote ER) or Valproic Acid (Depakene)
Divalproex or valproic acid can raise the level of Ativan in your blood, increasing your risk of Ativan side effects. Typically, your healthcare provider will need to lower your Ativan dosage (usually by 50 percent) if you are taking these drugs together.
 
Narcotics or Opiates
Combining an opiate or narcotic with Ativan can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk with your healthcare provider before taking Ativan with an opiate or narcotic.
 
Other Benzodiazepines
Combining Ativan with other benzodiazepines can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk with your healthcare provider before taking Ativan with another benzodiazepine.
 
Probenecid
Probenecid can raise the level of Ativan in your blood, increasing your risk of Ativan side effects. Typically, your healthcare provider will need to lower your Ativan dosage (usually by 50 percent) if you are taking these drugs together.
 
Seizure Medications
Combining a seizure medication with Ativan can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk with your healthcare provider before taking Ativan with a seizure medication.
 
Sleep Medications
Combining a sleep medication with Ativan can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk with your healthcare provider before taking Ativan with a sleep medication.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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