Drug Interactions With Chlordiazepoxide

When certain medications are taken with chlordiazepoxide, interactions can occur. Some of the medications that can cause drug interactions with chlordiazepoxide include antidepressant medications, antipsychotic medications, and sleep medications. These drug interactions can increase your risk of side effects, such as memory loss, confusion, drowsiness, and difficulty breathing.

 

An Overview of Drug Interactions With Chlordiazepoxide

 Chlordiazepoxide hydrochloride (Librium®) can potentially interact with numerous other medications, especially other medications that affect the brain. Some of these medicines that may lead to chlordiazepoxide interactions include:
 
o Clozapine (Clozaril®, FazaClo®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Telithromycin (Ketek®) 
  • Narcotics or opiates, such as morphine, oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
  • Other benzodiazepines, including:
  • Protease inhibitors, such as:
  • Seizure medications
  • Sleep medications.
     
(Drug Interactions With Chlordiazepoxide Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;