Clomipramine Dosing

Healthcare providers will consider several factors before prescribing clomipramine. The clomipramine dosing amounts are generally determined based on your age, existing medical conditions you may have, and other medications you may also be taking. The recommended starting clomipramine dose for treating obsessive-compulsive disorder is 25 mg once a day, preferably at bedtime. Your healthcare provider may slowly increase your clomipramine dose.

 

An Overview of Clomipramine Dosing

The dose of clomipramine hydrochloride (Anafranil®) your healthcare provider prescribes will vary depending on a number of factors, including:
 
  • Your age
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Clomipramine Dosing for OCD in Adults

For the treatment of obsessive-compulsive disorder (OCD) in adults, the recommended starting clomipramine dose is clomipramine 25 mg once daily. Your healthcare provider may slowly increase your dose (to 100 mg for most people) within two weeks. After that, the dose can be increased slowly up to clomipramine 250 mg per day if necessary.
 

Clomipramine Dosing for OCD in Children and Adolescents

For treating OCD in children and adolescents, the recommended starting clomipramine dose is clomipramine 25 mg once daily.
 Your healthcare provider may slowly increase your dose (up to 100 mg or about 1.4 mg per pound, whichever is smaller) within two weeks. After that, the dose can be increased slowly if necessary. The maximum dose for children and adolescents is clomipramine 200 mg or 1.4 mg per pound, whichever is smaller.
 
(Clomipramine Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;