A healthcare provider may prescribe clomipramine hydrochloride (Anafranil^®) to treat the symptoms of obsessive-compulsive disorder (OCD). It is thought that clomipramine works by helping to keep certain chemicals in the brain (norepinephrine and serotonin) stay in the brain longer, which can help relieve the symptoms of OCD. The medication comes in a capsule form that is taken one to three times a day. Because clomipramine can interact with other medications, it is important to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.