Drug Interactions With Clomipramine

If thyroid medications, alcohol, or certain antidepressants are taken together with clomipramine, interactions may occur. When a drug interaction with clomipramine occurs, the levels of clomipramine and other medications in your blood can increase, potentially increasing your risk of side effects. Some of these drug interactions can also increase your risk of a dangerous arrhythmia called QT prolongation. Therefore, be sure to talk to your healthcare provider about possible clomipramine drug interactions that may apply to you.

Drug Interactions With Clomipramine: An Introduction

 Clomipramine hydrochloride (Anafranil®) can potentially interact with many medicines. Some of the medicines that may lead to clomipramine interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
  • Phenothiazine medications, including:
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®)
  • Thyroid medications, including:
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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