More Safety Information on Clomipramine

Some Clomipramine Warnings and Precautions

Some clomipramine warnings and precautions to be aware of include:
  • Even though clomipramine is not licensed to treat depression, it is classified as an antidepressant based on how it works in the brain. Antidepressants (including clomipramine) may increase the risk of suicidal thinking or behavior in children, teenagers, and adults (see Depression and Suicide for more information). Therefore, if you notice any changes in symptoms or develop new symptoms, talk to your healthcare provider immediately. Some of these symptoms may include: anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thinking or behavior (see Clomipramine and Suicide for more information).
  • Before prescribing clomipramine, your healthcare provider should make sure that you do not have bipolar disorder, as clomipramine can cause problems in people with bipolar disorder.
  • Clomipramine can cause low white blood cell counts, which can increase your risk of infection. Tell your healthcare provider if you have symptoms of an infection, such as a fever or sore throat. Seek medical attention immediately if you have a very high fever, as this may be a sign of a dangerous side effect (hyperthermia).
  • Clomipramine can cause sexual problems, especially in men (see Clomipramine Sexual Side Effects). It can also cause weight gain (see Clomipramine and Weight Gain).
  • For people taking clomipramine, caution should be used when driving, operating heavy machinery, or performing other tasks that require concentration, especially when first starting clomipramine or when switching dosages. This is because clomipramine may affect a person's mental or physical ability to perform these tasks. Make sure to understand how clomipramine affects you before performing any task that requires mental or physical concentration.
  • Clomipramine can interact with certain medications (see Drug Interactions With Clomipramine).
  • Clomipramine may enhance the effects of alcohol, barbiturates, and other medicines that affect the brain. This can lead to an increased risk for drowsiness, dizziness, suicidal thoughts, and other clomipramine overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking clomipramine.
  • The U.S. Food and Drug Administration (FDA) considers clomipramine a pregnancy Category C medicine. This means that clomipramine may not be safe for use in pregnancy. Discuss the benefits and risks of using clomipramine during pregnancy with your healthcare provider (see Clomipramine and Pregnancy for more information).
  • Clomipramine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about what makes the most sense for your particular situation.
  • Special care should be used when taking clomipramine if you have seizures, heart disease, glaucoma, an adrenal tumor, liver problems, or kidney disease.
  • Talk to your healthcare provider before taking clomipramine if you have hyperthyroidism (an overactive thyroid) or take thyroid medication.
  • Do not stop taking clomipramine without first discussing it with your healthcare provider. Stopping the medicine abruptly may increase the risk of withdrawal symptoms (see Clomipramine Withdrawal).
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