Drug Interactions With Clonazepam

When clonazepam is taken with other medications, such as antidepressants and barbiturates, potentially negative interactions can occur. These drug interactions with clonazepam can lead to problems such as increased drug levels in the blood. As a result, this may increase your risk for side effects, such as difficulty breathing, memory loss, and drowsiness. To avoid these drug interactions, be sure to talk to your healthcare provider about any medications you are taking.

An Overview of Drug Interactions With Clonazepam

 Clonazepam (Klonopin®) can potentially interact with other medications. Some of these medicines that may lead to clonazepam interactions include:
 
o Clozapine (Clozaril®, FazaClo®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®) 
  • Protease inhibitors, such as:
  • Seizure medications
  • Sleep medications.
     
(Drug Interactions With Clonazepam Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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