Clorazepate Dosing

Clorazepate Dosing for Epilepsy

The recommended starting dose of clorazepate for controlling partial seizures in adults and adolescents age 12 and older is clorazepate 7.5 mg three times daily. Your healthcare provider may increase your dose as necessary, up to a maximum of 90 mg total per day.
 
For children ages 9 to 12, the recommended starting dose is clorazepate 7.5 mg twice daily. Your child's healthcare provider may increase the dose as necessary, up to a maximum of 60 mg per day.
 
Only the regular immediate-release clorazepate tablets are recommended for this use. Extended-release tablets should not be used for treating seizures. Also, it is important to remember that clorazepate is not approved to be used alone to treat partial seizures; it is only approved to be used in combination with other seizure medications.
 

General Information on Dosing With Clorazepate

Considerations for people taking clorazepate include the following:
 
  • The medication is available in short-acting tablets and long-acting tablets. It is usually taken one to three times daily (depending on the particular product and the dosage).
     
  • Clorazepate can be taken with or without food. If the medication bothers your stomach, try taking it with food.
     
  • For the medication to work properly, it must be taken as prescribed. Clorazepate may cause serious problems if you take it at higher dosages or for a longer period of time than your healthcare provider recommends (see Tranxene Addiction).
     
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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