Clorazepate Dosing: An Overview
The dose of
clorazepate (
Tranxene®) that your healthcare provider recommends will vary depending on a number of factors, including:
- Your age
- The medical condition being treated
- Other medications you may be taking
- Other medical conditions you may have.
As is always the case, do not adjust your clorazepate dose unless your healthcare provider specifically instructs you to do so.
Clorazepate Dosing for Alcohol Withdrawal
The recommended starting dose of clorazepate for alcohol withdrawal is clorazepate 30 mg for the first dose, followed by clorazepate 15 mg two to four times daily -- all within the first 24 hours. For a few days, the clorazepate dosage is usually slowly decreased, and the medication is stopped once you are stable.
Only the regular immediate-release clorazepate tablets are recommended for this use. Extended-release tablets should not be used for treating alcohol withdrawal.
Clorazepate Dosing for Anxiety
The recommended starting dose of clorazepate for the treatment of
anxiety is clorazepate 7.5 to 15 mg per day, either taken all at once at bedtime or split up into smaller doses throughout the day. Your healthcare provider may adjust your dose as necessary, increasing it if needed to control your
anxiety symptoms or decreasing it if you develop bothersome
side effects of clorazepate.
Immediate-release clorazepate tablets should be used in these cases when starting the drug and determining the best dose. Once you and your healthcare provider have found the best clorazepate dosage for you, you may be switched to extended-release tablets. People taking clorazepate 7.5 mg (immediate-release) three times daily can be switched to clorazepate 22.5 mg (extended-release) once daily. Those taking clorazepate 3.75 mg (immediate-release) three times daily may be switched to clorazepate 12.25 mg (extended-release) once daily.
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