What Is Clorazepate Used For?

Clorazepate is used for relieving symptoms associated with alcohol withdrawal and anxiety disorders, as well as partial seizures in people with epilepsy. It works by enhancing the effects of GABA in the brain. The medication typically is not given to children under nine years of age. Off-label clorazepate uses include the treatment of agitation, benzodiazepine withdrawal, and insomnia.

 

What Is Clorazepate Used For? -- An Overview

Clorazepate (Tranxene®) is a prescription medication that is used to treat the following conditions:
 

Why Is Clorazepate Used for Alcohol Withdrawal?

Quitting alcohol "cold turkey" is not always a good idea.
 In fact, it can be quite dangerous. People who drink heavily or frequently may experience alcohol withdrawal symptoms if they stop drinking alcohol too quickly. Mild withdrawal symptoms include:
 
  • Slight shakiness (the "shakes")
  • Alcohol cravings
  • Nervousness
  • Depression
  • Clammy skin.
     
More severe symptoms include:
 
  • Seizures
  • Delirium tremens (sometimes called "DTs"), a group of symptoms including confusion, agitation, and hallucinations
  • Severe nausea and vomiting
  • Very rapid heart rate (tachycardia).
     
Withdrawing from alcohol can be life threatening. It should always be done under a healthcare provider's supervision, and hospitalization is sometimes necessary. Clorazepate can help with agitation, shakiness, and delirium tremens associated with alcohol withdrawal.
 
(What Is Clorazepate Used For? Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;