Compazine Drug Interactions (Cont.)

 
Alcohol
In general, people taking Compazine should avoid alcohol (see Alcohol and Compazine).
 
Barbiturates
Compazine should not be combined with large doses of barbiturates, due to the increased risk of sedation and other problems.
 
Narcotics and Opiates
Compazine should not be combined with large doses of narcotics and opiates, due to increased risk of sedation and other problems.
 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Combining Compazine with propranolol may raise the levels of both medications in your blood, increasing your risk of side effects. Talk with your healthcare provider before using these medications together.
 
Seizure Medications
Compazine may make seizure medications less effective. Your healthcare provider may need to increase your doses of seizure medications.
 
Warfarin (Coumadin, Jantoven)
Compazine may make warfarin less effective. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary.
 

Final Thoughts on Compazine Drug Interactions

Not every drug interaction with Compazine was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the Compazine drug interactions that may apply to you. Because so many medications interact dangerously with Compazine, you should not take any medication (including non-prescription medications) without first talking with your healthcare provider.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;