Compazine Side Effects

Side Effects to Report

Some side effects with Compazine, while occurring infrequently, are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
 
  • An irregular heart rhythm (arrhythmia)
  • Low blood pressure (hypotension)
  • Severe constipation
  • High blood sugar (hyperglycemia) or low blood sugar (hypoglycemia)
  • Yellowing of the eyes or skin (jaundice)
  • Breast changes, such as breast enlargement or breast discharge
  • A painful erection of the penis that does not go away (known medically as priapism)
  • Worsening of psychotic symptoms
  • "Extrapyramidal symptoms," such as:
 
    • Unusual body, facial, or tongue movements
    • Muscle tension or contractions
    • Feelings of internal restlessness or jitteriness
 
  • Seizures
  • Signs or symptoms of neuroleptic malignant syndrome, which can include:
 
    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • An increased heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)
 
  • Signs of an allergic reaction, including:
 
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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