Compazine Warnings and Precautions

Prior to treatment with Compazine, warnings and precautions for the drug should be reviewed. You should let your healthcare provider know (before taking the drug) if you have glaucoma, breathing problems, or an enlarged prostate, among other conditions. Certain people should not take Compazine at all. Among the people who should avoid the drug are people who are taking large doses of medicines that cause drowsiness and children who are younger than two years of age or who weigh less than 20 pounds.

Compazine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Compazine® (prochlorperazine maleate) if you have:
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Drink alcohol.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Precautions and Warnings With Compazine

Some warnings and precautions to be aware of with Compazine include:
  • Compazine should not be used in children with Reye's syndrome. Symptoms of Reye's syndrome usually develop after a viral infection and may include:


    • Vomiting
    • Personality changes, such as irritability or combativeness
    • Disorientation or confusion
    • Seizures.


  • Compazine can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).

Tell your healthcare provider right away if think you might have NMS.

  • Compazine can cause tardive dyskinesia, a condition involving unusual uncontrollable body or face movements. The condition can become permanent (even if Compazine is stopped). The best way to prevent it from becoming permanent is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking Compazine.
  • Compazine can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how Compazine affects you before you do any activities that require mental concentration or physical coordination. Combining Compazine with medications or substances that cause drowsiness (such as narcotics, alcohol, or barbiturates) can be dangerous (see Alcohol and Compazine).
  • Before you take Compazine, you should let your healthcare provider know if you have breathing problems -- as Compazine could worsen these problems.
  • Compazine can increase your sensitivity to the sun, raising your risk of sunburn. You should use sunscreen before sun exposure while taking Compazine.
  • Compazine is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Be sure to talk with your healthcare provider about the risks and benefits of using Compazine during pregnancy (see Compazine and Pregnancy).
  • It is not known if Compazine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Compazine (see Compazine and Breastfeeding for more information).
  • Compazine can interact with certain other medications (see Compazine Drug Interactions).
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Compazine Drug Information

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