Doxepin Dosing

The recommended doxepin dose for people who are first starting depression or anxiety treatment is 75 mg daily, taken either as a single dose or split into several doses throughout the day. Depending on the effectiveness of the medication or whether side effects develop with doxepin, dosing guidelines may be adjusted accordingly. The maximum doxepin dosage is 300 mg per day.

Doxepin Dosage: An Overview

The dose of doxepin hydrochloride (Sinequan®, Silenor®) that your healthcare provider prescribes will vary depending on a number of factors, including:
  • Your age
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Doxepin Dosing for Depression or Anxiety

For depression or anxiety treatment, the recommended starting doxepin dose is 75 per day, either split up into smaller doses throughout the day or all at once before bedtime. Your healthcare provider may decide to lower your dose if side effects occur or increase your dose if symptoms are not adequately controlled. The maximum doxepin dose is 300 mg total per day.
Some people (especially those with mild anxiety or depression symptoms) may be able to take lower doses (such as doxepin 25 mg or 50 mg per day).

Doxepin Dosing for Insomnia

Only low-dose doxepin tablets (Silenor) are approved for insomnia treatment. The recommended starting dosage for insomnia in adults is Silenor 6 mg, taken within 30 minutes of bedtime. If necessary, your healthcare provider may decrease your dosage to 3 mg.
The standard dose of Silenor for elderly individuals (age 65 and older), who may be more sensitive to the effects of the drug, is 3 mg within 30 minutes of bedtime (with a dosage increase to 6 mg, if necessary). Also, people with liver problems should generally be started at the 3-mg dose.
For people taking cimetidine (Tagamet®), the maximum recommended dosage is Silenor 3 mg, since cimetidine increases the level of Silenor in the blood.
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Doxepin HCl

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