Serious Reactions to Doxepin

Side Effects to Report

There are a number of less common but more serious side effects that you should report to your healthcare provider, including but not limited to:
 
  • "Sleep driving" or performing other complex tasks while sleeping, often with no memory of the event
  • Excessive daytime drowsiness, especially if it impairs your ability to drive or operate heavy machinery
  • Heart attack or stroke
  • Change in heart rhythm (arrhythmia)
  • Fast heart rate (tachycardia) or feelings of a rapidly or forcefully beating heart (palpitations)
  • Seizures
  • Confusion, delusions, or hallucinations
  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing
  • Any breast changes, including breast enlargement or breast discharge
  • Swelling of the testicles
  • Yellowing of the eyes or skin (jaundice)
  • Suicidal thoughts or behavior (see Doxepin and Suicide)
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Restlessness or inability to sit still
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Difficulty sleeping
  • Anxiety, agitation, or panic attacks.
     

Final Thoughts

You may experience some or none of the doxepin side effects explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried.
 
Therefore, be sure to let your healthcare provider know if you develop any doxepin side effects or if something "just does not seem right." While it may not be related to doxepin, your healthcare provider will be able to diagnose and treat the problem.
 
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Doxepin HCl

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