Doxepin Side Effects

Common side effects of doxepin include drowsiness, weight gain, and dry mouth. In most cases, side effects are minor and either require no treatment or can easily be treated by a healthcare provider. However, certain side effects are more serious and should be reported to your healthcare provider right away, including signs of an allergic reaction, fast heart rate, and any breast changes.

An Introduction to Doxepin Side Effects

As with any medicine, there are possible side effects with doxepin hydrochloride (Sinequan®, Silenor®). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate the antidepressant well. When people do develop doxepin side effects, in many cases they are minor, meaning they require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, possible side effects with doxepin. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Doxepin

Doxepin has been studied thoroughly in clinical trials in which the side effects seen with a group of people taking the drug are documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of high-dose doxepin (for treating anxiety or depression) included:
Withdrawal side effects have been reported in people who have stopped taking doxepin suddenly (see Doxepin Withdrawal).
In clinical trials, low-dose doxepin (used to treat insomnia) was reported to cause the following common side effects:
  • Daytime drowsiness -- in up to 9 percent of people
  • Upper respiratory tract infection (such as the common cold) -- up to 4 percent
  • High blood pressure (hypertension) -- up to 3 percent
  • Nausea -- up to 2 percent
  • Gastroenteritis (commonly known as the "stomach flu") -- up to 2 percent.
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Doxepin HCl

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