An Introduction to Doxepin Side Effects
As with any medicine, there are possible side effects with
doxepin hydrochloride (
Sinequan®,
Silenor®). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate the
antidepressant well. When people do develop doxepin side effects, in many cases they are minor, meaning they require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, possible side effects with doxepin. Your healthcare provider can discuss a more complete list with you.)
Common Side Effects of Doxepin
Doxepin has been studied thoroughly in clinical trials in which the side effects seen with a group of people taking the drug are documented and compared to another group not taking the medicine.
This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of high-dose doxepin (for treating
anxiety or
depression) included:
Withdrawal side effects have been reported in people who have stopped taking doxepin suddenly
(see Doxepin Withdrawal).
In clinical trials, low-dose doxepin (used to treat
insomnia) was reported to cause the following common side effects:
- Daytime drowsiness -- in up to 9 percent of people
- Upper respiratory tract infection (such as the common cold) -- up to 4 percent
- High blood pressure (hypertension) -- up to 3 percent
- Nausea -- up to 2 percent
- Gastroenteritis (commonly known as the "stomach flu") -- up to 2 percent.
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