Doxepin Withdrawal

 Doxepin hydrochloride (Sinequan®) and other antidepressants are known to cause withdrawal symptoms in those who quickly stop their medicine.
 
Certain doxepin withdrawal symptoms can include, but are not limited to:
 
  • Irritability
  • Agitation
  • Dizziness
  • Burning or tingling sensation
  • Anxiety
  • Confusion
  • Headache
  • Insomnia
  • Tiredness
  • Nausea
  • Malaise (a general ill feeling).
     
In most people, these doxepin withdrawal symptoms improve with time without the need for any treatment.
 
If you are going to be taken off of doxepin, your healthcare provider may decide to wean you off slowly to minimize the chances of developing withdrawals from doxepin. If withdrawal symptoms do occur, your healthcare provider may return you to your previous doxepin dosage and then wean you off even slower.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;