Medications That Interfere With Doxepin

Doxepin Interactions Explained

The following sections explain in detail the potential interactions that can occur when doxepin is combined with any of the drugs listed above. 
 
Alcohol
Doxepin may enhance the effects of alcohol. This can lead to an increased risk for suicidal thoughts and other doxepin overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking doxepin.
 
Anticholinergic Medications
Taking doxepin with anticholinergic medications may increase the risk of side effects. Talk to your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these types of medicines are found in over-the-counter medicines, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.
 
Arrhythmia Medications
Taking doxepin with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of doxepin in your blood, increasing your risk for side effects. Talk to your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking doxepin with cimetidine can increase the level of doxepin in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking doxepin with MAOIs can increase your chance of developing dangerous side effects. Do not take doxepin if you have taken an MAOI within the past two weeks.
 
Phenothiazines
Taking doxepin with phenothiazine medications can increase the level of doxepin in your blood, increasing your risk of side effects. Also, combining doxepin with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.
 
SSRI or SNRI Medications
Taking doxepin with SSRI or SNRI medications could increase your chance of side effects. Check with your healthcare provider before taking such medications together.
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Doxepin HCl

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