Drug Interactions With Doxepin

Drug interactions with doxepin can potentially increase the level of doxepin in your blood and lead to dangerous side effects. Medicines that may cause an interaction when taken together with doxepin include arrhythmia medications, cimetidine, phenothiazine medications, and other tricyclic antidepressants. Potential side effects of doxepin drug interactions include suicidal thoughts and low blood sugar, among other things.

 

Drug Interactions With Doxepin: An Introduction

 Doxepin hydrochloride (Sinequan®) can potentially interact with many medicines. Some of the medicines that may lead to doxepin drug interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®)
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
(Drug Interactions With Doxepin Continued: Page 2)
Add this article to your Favorites     Email this article     Print
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;