Drug Interactions With Duloxetine

The following sections explain in detail the potentially negative interactions that can occur when duloxetine is combined with any of the drugs listed above.

 

It is not recommended to drink alcohol while taking duloxetine. Combining alcohol and duloxetine together may cause unwanted side effects (see Cymbalta and Alcohol).

 

Taking duloxetine with certain arrhythmia medications can increase the level of duloxetine or the arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.

 

Taking duloxetine with certain fluoroquinolone antibiotics can increase the level of duloxetine in your blood, increasing your risks of side effects. Your healthcare provider may need to decrease your duloxetine dose or may suggest a different antibiotic.

 

Taking delavirdine with duloxetine can increase the level of duloxetine in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your duloxetine dosage.

 

Taking duloxetine with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.