Drug Interactions With Duloxetine

There are potential drug interactions with duloxetine. Taking duloxetine with other medications, such as certain arrhythmia medications, some antibiotics, and MAOIs, can lead to problems. Some of these interactions can increase the levels of duloxetine and other medications in your blood, potentially increasing your risk of side effects. Other drug interactions could cause dangerous conditions, such as serotonin syndrome or QT prolongation.

Drug Interactions With Duloxetine: An Introduction

Duloxetine hydrochloride (Cymbalta®) can potentially interact with a number of medicines. Some of the medicines that can lead to duloxetine interactions include:
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
  
 
  
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Pergolide (Permax®)
  • Phenothiazine medications, including:

 

 

 

 

 

 

 

 

Drug Interactions With Duloxetine Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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