Treatment Guidelines for Duloxetine

Duloxetine Dosing for Anxiety
The recommended duloxetine dose for generalized anxiety disorder is duloxetine 60 mg once daily. Your healthcare provider may decide to start you at a lower dose (duloxetine 30 mg once daily) for a week before increasing you to duloxetine 60 mg once daily, although this is not necessary for everyone.
Duloxetine Dosing for Fibromyalgia
The recommended starting dose for fibromyalgia treatment is duloxetine 30 mg once a day for one week, after which your healthcare provider may increase the dose to duloxetine 60 mg once daily.
Duloxetine Dosing for Musculoskeletal Pain
The standard recommended dosage for treating chronic musculoskeletal pain (such as arthritis pain or back pack) is duloxetine 60 mg once daily. In some cases, your healthcare provider may decide to start you with a lower dose (30 mg once daily) for a week to help you become accustomed to the drug.

General Duloxetine Dosing Information

Some considerations for people taking duloxetine include:
  • It usually takes several weeks (perhaps even more than a month) before feeling the beneficial effects of duloxetine. Try not to be discouraged if duloxetine does not work right away for you.
  • Duloxetine capsules should not be opened or chewed. Make sure to swallow duloxetine capsules whole.
  • If duloxetine makes you drowsy, try taking it later in the day. If duloxetine causes insomnia for you, try taking it earlier in the day.
  • You can take duloxetine with or without food. If duloxetine bothers your stomach, try taking it with food.
  • Duloxetine should be taken at the same time(s) each day to maintain an even level of the drug in your blood.
  • Abruptly stopping medications like duloxetine can result in withdrawal symptoms (see Cymbalta Withdrawal for more information).
  • For duloxetine to work properly, you have to take it as prescribed. Duloxetine will not work if you take it differently than how your healthcare provider prescribed it.
  • If you are unsure about anything related to duloxetine or your duloxetine dosage, please talk to your doctor, nurse, or pharmacist. Do not stop taking duloxetine without first discussing it with your healthcare provider.
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