Effexor XR Alternatives

Therapy as an Effexor XR Alternative

Many forms of psychotherapy, including some short-term (10 to 20 weeks) therapies, can help people with depression. "Talk" therapies help patients gain insight into and resolve their problems through verbal exchange with the therapist, sometimes combined with "homework" assignments between sessions. Behavioral therapists help patients learn how to obtain more satisfaction through their own actions and how to unlearn the behavioral patterns that contribute to, or result from, their depression.
 
(Click Psychotherapy for Depression to learn more about this depression treatment option.)
 

Other Depression Medications

Fortunately, there are many medications available to treat depression. These medications can include:
 
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Serotonin-norepinephrine reuptake inhibitors (SNRIs) increase the level of serotonin and norepinephrine available for the cells of the brain. Effexor XR is an SNRI. In addition to Effexor XR (and Effexor, the short-acting version), there are two other SNRIs used to treat depression: duloxetine (Cymbalta®) and desvenlafaxine (Pristiq®).
 
Milnacipran (Savella™) is an SNRI that is not approved for the treatment of depression (although it may be used off-label for this purpose).
  
Selective Serotonin Reuptake Inhibitors (SSRIs)
SSRIs are usually very effective at treating depression and usually do not have many serious side effects. They work by increasing the level of serotonin available for cells of the brain. In addition to Effexor XR, these medications can include:
 
Monoamine Oxidase Inhibitors (MAOIs)
Monoamine oxidase inhibitors are a class of older medications used for treating depression. There are many serious food and drug interactions with MAOIs. Because of this, MAOIs are usually used only if other medications for depression have not been effective. A few examples of MAOIs include:
 
Tricyclic Antidepressants
Tricyclic antidepressants are another older class of antidepressants. Due to certain side effects, they are generally not recommended for elderly people. Tricyclic types of depression medicine can include:
 
Miscellaneous Antidepressants
There are several other antidepressants available, including:
 

 

Sometimes, stimulant medications such as methylphenidate (Ritalin®) are used to treat depression when other medications have not helped, though stimulants are not approved for this use.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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