Drugs That Can Interfere With Escitalopram

Escitalopram and Serotonin Syndrome

Several of the known interactions with escitalopram are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Interactions With Escitalopram Explained

The following sections explain in detail the potentially negative interactions that can occur when escitalopram is combined with any of the drugs listed above.
It is not recommended that you drink alcohol while taking escitalopram. Combining alcohol and escitalopram may cause unwanted side effects (see Alcohol and Lexapro).
Taking escitalopram and aspirin together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking aspirin and escitalopram together.
Buspirone (BuSpar)
Because combining escitalopram with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Cimetidine (Tagamet)
Taking cimetidine and escitalopram together can increase the level of escitalopram in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your escitalopram dose or may suggest an alternative to cimetidine.
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