Additional Products That Interfere With Fluoxetine

Lithium (Eskalith, Lithobid)
Fluoxetine may increase or decrease the level of lithium in your blood, perhaps making it less effective or increasing your risk of side effects. Also, taking fluoxetine with lithium can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Medications That Prolong the QT Interval
Many different medications, including fluoxetine, can cause a change in the heart rhythm known as QT prolongation, which can be very dangerous. Combining fluoxetine with other QT-prolonging medications increases the risk of a life-threatening arrhythmia (torsade de pointes) caused by excessive QT prolongation. Check with your healthcare provider before combining such medications.
 
Miscellaneous Antidepressants
Combining fluoxetine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking fluoxetine and an MAOI together can cause life-threatening side effects. Never take an MAOI and fluoxetine at the same time, and do not take fluoxetine if you have taken an MAOI within the past 14 days. Also, because fluoxetine stays in your system for so long, do not take an MAOI if you have taken fluoxetine within the past five weeks.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking fluoxetine and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking NSAIDs and fluoxetine together.
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