Drug Interactions With Fluoxetine

Sometimes when different medications are taken together, it is possible to develop negative drug interactions. With fluoxetine, medicines that may cause a drug interaction include nonsteroidal anti-inflammatory drugs, warfarin, aspirin, and monoamine oxidase inhibitors. Drug interactions with fluoxetine may increase the level of medicines in your system and increase your risk for developing serious side effects, among other things.

 

Fluoxetine Drug Interactions: An Introduction

 Fluoxetine hydrochloride (Prozac®) can potentially interact with a number of medicines. Some of the medicines that can lead to fluoxetine interactions include:
 
o Pimozide (Orap®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
o Ketoprofen (Orudis®)
  • Tryptophan
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Fluoxetine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;