Drugs That Interfere With Fluvoxamine

Fluvoxamine and Serotonin Syndrome

Several of the known interactions with fluvoxamine are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Fluvoxamine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when fluvoxamine is combined with any of the drugs listed above.
It is not recommended that you drink alcohol while taking fluvoxamine. Combining alcohol and fluvoxamine together may cause unwanted side effects (see Alcohol and Luvox).
Alosetron (Lotronex)
Taking alosetron and fluvoxamine together can greatly increase the level of alosetron in your blood, increasing your risk of side effects. It is not recommended that you take these two medications together.
Antipsychotic Medications
Taking fluvoxamine with antipsychotic medications may increase your risk of neuroleptic malignant syndrome (NMS). Symptoms of NMS can include a fever, muscle tension, changes in heart rate and blood pressure, and mental changes (such as confusion). Tell your healthcare provider right away if you are having symptoms of NMS.
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