Drug Combinations With Fluvoxamine to Avoid

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking fluvoxamine and NSAIDs together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking NSAIDs and fluvoxamine together.
 
Pimozide (Orap)
Pimozide and fluvoxamine should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.
 
Propranolol (Inderal, Inderal LA, Innopran XL)
Fluvoxamine can raise the level of propranolol in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your dose of propranolol.
 
SSRI or SNRI Medications
Taking fluvoxamine with other SSRI or SNRI medications can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking fluvoxamine with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tacrine (Cognex)
Taking tacrine and fluvoxamine together can raise the level of tacrine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your tacrine dose.
 
Theophylline
Fluvoxamine can raise the level of theophylline in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood, especially when you are starting or stopping fluvoxamine.
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