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Drug Interactions With Fluvoxamine
Taking fluvoxamine together with certain other drugs -- such as antipsychotic medications, aspirin, and MAOIs -- can potentially cause drug interactions. Fluvoxamine drug interactions can change the levels of some medications in your blood or increase your risk of side effects, among other things. You should be sure to talk with your healthcare provider about the drug interactions with fluvoxamine that may apply to you.
Drug Interactions With Fluvoxamine: An Introduction
Fluvoxamine maleate (Luvox®) can potentially interact with many other medicines. Some of the medicines that can lead to fluvoxamine interactions include:- Alcohol
- Alosetron (Lotronex®)
- Antipsychotic medications, such as clozapine (Clozaril®), olanzapine (Zyprexa®, Symbyax®), quetiapine (Seroquel®), risperidone (Risperdal®), thioridazine (Mellaril®), and many others
- Aspirin
- Buspirone (BuSpar®)
- Certain benzodiazepines, including:
- Alprazolam (Xanax®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clobazam (Onfi™)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Diazepam (Valium®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Midazolam (Versed®)
- Quazepam (Doral®)
- Triazolam (Halcion®)
- Linezolid (Zyvox®)
- Lithium (Eskalith®, Lithobid®)
- Methadone (Dolophine®, Methadose®)
- Metoprolol (Lopressor®, Toprol XL®)
- Mexiletine (Mexitil®)
- Miscellaneous antidepressants, such as:
- Bupropion (Aplenzin™, Budeprion XL®, Budeprion™ SR, Buproban®, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin®, Zyban®)
- Mirtazapine (Remeron®)
- Nefazodone (Serzone®)
- Trazodone (Desyrel®) or trazodone ER (Oleptro™)
- Vilazodone (Viibryd™)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Ibuprofen (Motrin®, Advil®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Diclofenac (Cataflam®, Voltaren®)
- Indomethacin (Indocin®)
- Nabumetone (Relafen®)
- Oxaprozin (Daypro®)
- Celecoxib (Celebrex®)
- Meloxicam (Mobic®)
- Etodolac (Lodine®)
- Ketoprofen (Orudis®)
- Ketorolac (Toradol®)
- Pimozide (Orap®)
- Propranolol (Inderal®, Inderal LA®, Innopran XL®)
- Other SSRI or SNRI medications, such as:
- Citalopram (Celexa®)
- Desvenlafaxine (Pristiq™)
- Duloxetine (Cymbalta®)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Fluvoxamine CR (Luvox® CR)
- Levomilnacipran (Fetzima™)
- Milnacipran (Savella™)
- Paroxetine (Paxil®, Paxil CR®, Pexeva®, Brisdelle™)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- St. John's wort
- Tacrine (Cognex®)
- Theophylline
- Tizanidine (Zanaflex®)
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Triptans, including:
- Almotriptan (Axert®)
- Eletriptan (Relpax®)
- Frovatriptan (Frova®)
- Naratriptan (Amerge®)
- Rizatriptan (Maxalt®)
- Sumatriptan (Alsuma™, Imitrex®, Sumavel®, Zecuity™) or sumatriptan/naproxen sodium (Treximet®)
- Zolmitriptan (Zomig®)
- Tryptophan
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD