Drug Combinations With Luvox to Avoid

Pimozide (Orap)
Pimozide and Luvox should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.
 
Propranolol (Inderal, Inderal LA, Innopran XL)
Luvox can raise the level of propranolol in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your dose of propranolol.
 
SSRI or SNRI Medications
Taking Luvox with other SSRI or SNRI medications can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Luvox with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tacrine (Cognex)
Taking tacrine and Luvox together can raise the level of tacrine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your tacrine dose.
 
Theophylline
Luvox can raise the level of theophylline in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood, especially when you are starting or stopping Luvox.
 
Tizanidine (Zanaflex)
Taking tizanidine and Luvox together can raise the level of tizanidine in your blood, increasing your risk of side effects. These two medications should not be taken together.
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