Ensuring Safe Treatment With Luvox

Some Luvox Warnings and Precautions

Some warnings and precautions to be aware of with Luvox include:
  • Luvox can interact with many other medicines (see Luvox Drug Interactions). Many of these interactions are very serious. Always check with your healthcare provider before taking any medications (including non-prescription medications) with Luvox.
  • Even though Luvox is not licensed to treat depression, it is classified as an antidepressant based on how it works in the brain. Antidepressants (including Luvox) may increase the risk of suicidal thoughts or behavior in children, teenagers, and adults (see Antidepressants and Suicide for more information). Therefore, if you notice any changes in symptoms or develop new symptoms while taking Luvox, be sure to talk with your healthcare provider immediately. Some of these symptoms include anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thoughts or behavior (see Luvox and Suicide for more information).
  • Before prescribing Luvox off-label for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). Sometimes, the symptoms of bipolar disorder and depression are very similar, and Luvox can cause problems in people with bipolar disorder.
  • Smoking usually decreases the level of Luvox in your blood. If you start smoking (or quit smoking), your healthcare provider may need to adjust your Luvox dosage.
  • If you have a seizure disorder, there is a possibility that taking Luvox may cause seizures. Talk with your healthcare professional before taking Luvox if you have seizures.
  • If you are stopping Luvox, you should be monitored by a healthcare professional for withdrawal symptoms. If you do develop any symptoms of a Luvox withdrawal -- such as irritability, anxiety, confusion, headaches, lethargy, or insomnia -- your healthcare provider may slow down the rate at which he or she is decreasing your Luvox dosage (see Luvox Withdrawal).
  • Luvox may cause bleeding in the stomach or intestines. This risk is increased in those taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen. Symptoms of gastrointestinal bleeding may include:


    • Bright red blood coating the stool
    • Dark blood mixed with the stool
    • Black or tarry stool
    • Bright red blood in vomit
    • Vomit that has the appearance of coffee grounds.
If you experience any of these symptoms, call your healthcare provider.
  • If you are elderly or are taking a diuretic, Luvox could cause low salt levels in the blood (hyponatremia). These levels generally return to "normal" when Luvox is stopped.
  • If you have liver problems, you may need a lower Luvox dose (and your dose should be increased very slowly and only if needed), as the liver helps to remove Luvox from the blood.
  • Luvox may affect your ability to perform complex tasks requiring mental and motor skills. Therefore, it is recommended that you become accustomed to its effect on you before becoming involved in activities requiring mental or motor concentration (such as driving a car or operating machinery). This effect may be greater if you are taking other medications that make you drowsy.
  • Luvox can cause rashes or other allergic reactions. If you develop an unexplained rash or hives during treatment with Luvox, talk with your healthcare provider.
  • Luvox is considered a pregnancy Category C medication. This means that Luvox may not be safe to use during pregnancy. Talk with your healthcare provider about the risks and benefits of using Luvox during pregnancy (see Luvox and Pregnancy for more information).
  • Luvox passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Luvox (see Luvox and Breastfeeding).
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