Clomipramine is a drug used to treat obsessive-compulsive disorder. It is not entirely clear how the drug works, but it is thought to help alleviate the symptoms of OCD by allowing certain chemicals to stay in the brain longer. The medication comes in tablet form and is generally taken one to three times a day. Prior to taking clomipramine, tell your healthcare provider if you have bipolar disorder, allergies, or heart problems.
Clomipramine is made by Mallinckrodt Pharmaceuticals. Generic clomipramine is made by several manufacturers of generic medications.
How Does Clomipramine Work?
Clomipramine belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how the medication works. Clomipramine does affect several chemicals in the brain, including serotonin and norepinephrine. Perhaps the medication allows these chemicals to stay in the brain longer, which can help with symptoms of OCD.
Even though clomipramine is classified as a tricyclic antidepressant (due the chemical structure of the molecule), it actually acts much like a selective serotonin reuptake inhibitor (SSRI). SSRIs are a newer group of antidepressant medications, and many people consider clomipramine to be an SSRI, even though it is technically a tricyclic antidepressant.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed February 22, 2007.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed February 22, 2007.
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