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Clomipramine and Serotonin Syndrome

Several of the known interactions with clomipramine are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 

Clomipramine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when clomipramine is combined with any of the drugs listed above.
 
Alcohol
Clomipramine may enhance the effects of alcohol. Be sure to talk with your healthcare provider about drinking alcohol while taking clomipramine.
 
Anticholinergic Medications
Taking clomipramine with anticholinergic medications may increase your risk of side effects. Talk to your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these types of medicines are found in over-the-counter medicines. Therefore, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.
 
Arrhythmia Medications
Taking clomipramine with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of clomipramine in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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