Anxiety Home > Medications That Interfere With Clomipramine

Barbiturates
Taking clomipramine with barbiturates can increase the risk of side effects of both clomipramine and barbiturates, such as drowsiness or dizziness. It is also possible that taking these medications together could decrease the level of clomipramine in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Buspirone (BuSpar)
Because combining clomipramine with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking clomipramine with cimetidine can increase the level of clomipramine in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your clomipramine dosage or suggest an alternative to cimetidine.
 
Clonidine (Catapres)
Clomipramine may make clonidine less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Digoxin (Digitek, Lanoxin)
Taking clomipramine with digoxin can increase the effects of digoxin, which can lead to dangerous side effects. Your healthcare provider may need to monitor you more closely or adjust your digoxin dosage.
 
Fentanyl
Combining clomipramine with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking clomipramine with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining clomipramine with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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