Anxiety Home > Drug Interactions With Clomipramine

If thyroid medications, alcohol, or certain antidepressants are taken together with clomipramine, interactions may occur. When a drug interaction with clomipramine occurs, the levels of clomipramine and other medications in your blood can increase, potentially increasing your risk of side effects. Some of these drug interactions can also increase your risk of a dangerous arrhythmia called QT prolongation. Therefore, be sure to talk to your healthcare provider about possible clomipramine drug interactions that may apply to you.

Drug Interactions With Clomipramine: An Introduction

Clomipramine hydrochloride (Anafranil®) can potentially interact with many medicines. Some of the medicines that may lead to clomipramine interactions include:
  • Barbiturates, including:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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