Compazine is a prescription medicine that is used for treating anxiety, schizophrenia, and severe nausea or vomiting. By blocking or lessening the effects of dopamine in the brain, the medication can help improve these conditions. Compazine comes in various forms, including tablets, rectal suppositories, and injections. Some of the most common side effects reported with the drug include blurred vision, drowsiness, dizziness, and a dry mouth.
What Is Compazine?
Part of a group of drugs called phenothiazines, Compazine® (prochlorperazine maleate) is a prescription medicine that has been licensed to treat the following conditions:
Compazine was originally manufactured by GlaxoSmithKline. Although brand-name Compazine is no longer being made, generic Compazine is still available. Generic Compazine is made by several different companies.
Compazine belongs to a group of medications called phenothiazines. When used to treat schizophrenia, it is known as a typical (or first-generation) antipsychotic medication. It is not entirely known exactly how Compazine works. However, it is known that the drug blocks or lessens the effects of dopamine, a chemical in the brain. Dopamine may be elevated in people with schizophrenia or anxiety. Compazine is not a cure for schizophrenia or anxiety; it only helps to control symptoms of these conditions (see Symptoms of Schizophrenia or Anxiety Symptoms).
Since dopamine can activate the part of the brain that controls nausea and vomiting, this medication can treat severe nausea and vomiting by lessening the effects of dopamine in the brain.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Compazine [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2004 July.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 25, 2007.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 25, 2007.
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