Anxiety Home > Duloxetine Side Effects

Drowsiness, nausea, and headaches are common side effects that have been reported with duloxetine. Side effects that are less common include canker sores, high cholesterol, and acne. Although most people tolerate the medication well and, in many cases, the side effects are minor, you should seek medical attention if you develop suicidal thoughts, hallucinations, or any signs of an allergic reaction.

Side Effects of Duloxetine: An Introduction

As with any medicine, side effects are possible with duloxetine hydrochloride (Cymbalta®). However, not everyone who takes the drug will experience problems. In fact, most people tolerate it well. If side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with duloxetine. Your healthcare provider can discuss a more complete list of duloxetine side effects with you.)
 

Duloxetine Side Effects to Report

Some side effects with duloxetine, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Suicidal thoughts or behavior (see Cymbalta and Suicide)
  • Anxiety, agitation, or panic attacks
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Restlessness or inability to sit still
  • Extreme elation or feelings of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Signs of serotonin syndrome (a rare but dangerous problem associated with certain medications), such as:
     
    • Confusion or other mental changes
    • A rapid heart rate
    • Nausea, vomiting, or diarrhea
    • Hallucinations
    • Blood pressure changes
    • An irregular heart rhythm
    • Overactive reflexes
    • Fever, sweating, or shivering
    • Shakiness
    • Agitation
    • Seizures
    • Coma
 
  • Low blood sugar (hypoglycemia)
  • Chest palpitations
  • Difficulty passing urine
  • Signs of an allergic reaction, including:
 
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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