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Effexor XR and Serotonin Syndrome

Several of the known interactions with Effexor XR are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Effexor XR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Effexor XR is combined with any of the drugs listed above.
It is not recommended that you drink alcohol while taking Effexor XR. Combining alcohol and Effexor XR may cause unwanted side effects (see Alcohol and Effexor XR).
"Blood Thinners"
Combining Effexor XR with anticoagulant or antiplatelet medications (commonly known as blood thinners) may increase the risk of bleeding. Check with your healthcare provider before taking such medications with Effexor XR.
Buspirone (BuSpar)
Because combining Effexor XR with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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