Anxiety Home > More Drugs That React With Effexor XR

Lithium (Eskalith, Lithobid)
Taking Effexor XR with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining Effexor XR with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Effexor XR and an MAOI together can cause life-threatening side effects. Do not take Effexor XR if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken Effexor XR within the past seven days.
 
SSRI or SNRI Antidepressants
Taking Effexor XR with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Effexor XR with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking Effexor XR with tramadol can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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