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Paroxetine Controlled Release and Serotonin Syndrome

Several of the known interactions with paroxetine controlled release are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:


  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.

Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.


Paroxetine Controlled Release Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when paroxetine controlled release is combined with any of the drugs listed above.



It is not recommended that you drink alcohol while taking paroxetine controlled release. Combining alcohol and paroxetine controlled release may cause unwanted side effects (see Alcohol and Paxil CR).



Taking paroxetine controlled release and aspirin together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking aspirin and paroxetine controlled release together.


Atomoxetine (Strattera)

Paroxetine controlled release can raise the level of atomoxetine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your atomoxetine dosage.

Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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