Anxiety Home > Drug Interactions With Paroxetine Controlled Release

A number of medications can potentially cause drug interactions with paroxetine controlled release, including nonsteroidal anti-inflammatory drugs (NSAIDs), digoxin, certain arrhythmia medications, and aspirin. Paroxetine controlled release drug interactions can change the levels of some medicines in your blood and increase your risk of serotonin syndrome or other side effects.

Drug Interactions With Paroxetine Controlled Release: An Introduction

Paroxetine controlled release (Paxil CR®) can potentially interact with a number of other medicines. Some of the medicines that can lead to paroxetine controlled release interactions include:


  • Monoamine oxidase inhibitors (MAOIs), including:



  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:



  • Phenothiazine medications, including:









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Last reviewed by: Kristi Monson, PharmD;
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